Center for Genetic Physiology

Facility/Node
Centre for Genetic Physiology

Contact person
Anders Arner (anders.arner@fyfa.ki.se)

Facility website: http://ki.se/ki/jsp/polopoly.jsp?d=3831&a=1330&l=en

Summary of service
A centre for genetic physiology is housed in the bottom floor of house 95:21 within the Department of Physiology and Pharmacology. The focus is on methods to characterize genetically modified mice.

Technologies/Methods
In vivo methods
Mouse telemetry
A sender is operated into the mouse abdomen, the mouse kept in a cage with a transmitter, and ECG, body temperature, and locomoter activity is registered for up to 6 weeks.
OxyMax system
This is a cage where O2, CO2 and temperature are registered. It can be combined with exercise (tread-mill system) and telemetry.
In vivo blood pressure
Can be measured externally (tail cuff system) or invasively (swivel system with a catheter in the femoral or carotid artery).
Mouse echocardiography
A high resolution equipment can evaluate left ventricular function, aortic or mitral valve flow, as in humans with calculations of ejection fraction, wall thickening etc.
Ex vivo models
Isolated heart model
The isolated, modified Langendorff-setup is established

Organ bath
An organ bath system with 4 chambers for studies of vessel reactivty in arterial/venous rings.

Practical information
For more information on service and prices please send an email to phenotype@ki.se.

Details/theories of technology